For a variety of reasons, including patent extensions, new therapeutic developments and marketing, to name a few, pharmaceutical companies are increasingly developing bi-layer tablets.

Making Bi-Layer Tablets

To reduce capital investment, modified tablet presses are used to develop and produce such tablets; however, to manufacture quality bi-layer tablets and overcome issues with layer separation, insufficient hardness, inaccurate individual layer weight control, cross-contamination between the layers, reduced yield, etc., the process should be done using purpose-built machinery. Using a modified tablet press may not be the best way to produce a quality bi-layer tablet under GMP conditions, especially when high production output is also required. Making bi-layer tablets with a standard press can be difficult. The majority of double-sided tablet presses with automated production control are limited by their use of compression force to monitor and control tablet weight: separation of the two individual layers is often a problem – a consequence of insufficient bonding between the two layers during final compression. It is essential to measure the weight of each layer independently to ensure the correct drug delivery profile; however, most tablet presses can only accurately assess weight when a high force is applied. High forces result in dense tablets that are difficult to bond together, making separation of the layers, or capping, almost inevitable.

GEA Compression Technology

GEA MODUL™ Tablet Press

GEA’s double-sided tablet presses have been specifically designed and developed for the production of quality bi-layer tablets and provide

  • displacement weight monitoring/control for accurate and independent weight control of the individual layers
  • low compression force exerted on the first layer to avoid capping and separation of the two individual layers
  • increased dwell time at pre-compression of both first and second layer to provide sufficient hardness at maximum turret speed
  • maximum prevention of cross-contamination between the two layers
  • a clear visual separation between the two layer
  • maximized yield.

The GEA process uses tablet height at pre-compression to calculate weight, not force applied. This means that the weight can be calculated accurately at low compression forces, leaving the final bonding of the two layers and the density control to be achieved at main compression.

How It’s Done

The unique GEA method is both simple and effective. It uses the Air Compensator-derived dual control system to measure the height (and, therefore, the weight) of the first layer at pre-compression. The main compression force for the first layer remains relatively low. The second layer is then filled on top of the first layer and the height is measured at pre-compression in the same way. Main compression of the second layer bonds the layers together and measures the force applied to calculate the hardness of each bi-layer tablet. This process provides very accurate weight control of each layer, ensures optimum bonding and provides the consistent hardness required. Bi-layer tablet production using this unique method is only available on the GEA MODUL™ D tablet press.


  • Accurate weight control for both layers at pre-compression
  • Effective bonding
  • Accurate tablet hardness control at main compression.


Dishwasher Tablets

GEA’s double-sided or double-layer R253 and/or the triple layer R353 rotary tablet press are the best options for the high output, low maintenance compression of detergent tablets. For multilayer tablets, cross-contamination between the different layers must be avoided and different colors must be separated with a clear straight line. Each layer benefits from a separate cyclone-based dust extraction system and the extracted powder can be subsequently recycled.

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